Large de-identified administrative datasets are a very valuable existing source of information that can be used to inform health policy. Data linkage is a rapidly expanding field which further substantially increases the amount of useful information available to researchers. CIs and AIs on this CRE application (Professor McIntyre, Dr Menzies) have extensive experience in the use of many administrative datasets, including the National Hospital Morbidity Database through a Research Associate’s agreement with the Australian Institute of Health and Welfare, and nationally notified vaccine preventable diseases through ‘trusted stakeholder’ status with the Communicable Disease Network Australia. In addition, NCIRS is the only organisation to have experience with analysis of the ACIR and Adverse Events Following Immunisation (AEFI) reported to the Therapeutic Goods Administration. Dr Bette Liu, a NHMRC post-doc, has extensive experience with linked data.